Appendices: Donepezil, rivastigmine, galantamine and memantine for Alzheimer’s disease

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  • E Loveman
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Submission on Behalf of the British Geriatrics Society to the National Institute for Clinical Excellence Health Technology Appraisal: Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common cause of dementia and is a progressive neurodegenerative illness for which at present there is no cure. The management involves both nonpharmacological and pharmacological approaches. This submission will concentrate mostly on the acetylcholinesterase inhibitors (AChEI), donepezil, rivastigmine and galantamine as well as the NMDA receptor antagonist m...

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Alzheimer’s disease is a serious progressive neurodegenerative disorder with devastating consequences for the patient. Donepezil has a significant body of clinical evidence, previously accepted by NICE and restated in the Eisai/Pfizer submission, that demonstrates the efficacy of donepezil in the symptomatic management of both mild and moderate AD. This evidence base shows that donepezil delays...

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Rivastigmine, galantamine, and memantine, in addition to donepezil, which has been on the market over 10 years, have been available for the treatment of Alzheimer's disease (AD) since 2011 in Japan, leading a new stage in the medical treatment of AD. We studied two AD patients showing sudden deterioration of behavioral and psychological symptoms of dementia (BPSD) associated with switching from...

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Alzheimer’s disease (AD) is a well known progressive neurodegenerative disorder having complex pathophysiology. Currently, drugs that are used symptomatically in the treatment of AD include acetylcholinesterase inhibitors (AChEIs) (rivastigmine, galantamine, donepezil) and N-methyl D-aspartate (NMDA) receptor antagonist (memantine). Limited bioavailability of these drugs stresses continuity of ...

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تاریخ انتشار 2005